Gene Expression Signatures and the Spectrum of Coronary Artery Disease.

Journal Article (Journal Article;Review)

Over the past 10-15 years, developments in gene expression profiling have opened new arenas for the discovery of important factors in the pathogenesis of numerous disease processes, including coronary artery disease. Messenger RNA and microRNA are differentially expressed in patients with coronary plaques, acute plaque rupture, and response to well-established treatments for acute coronary syndromes. In this review, we will explore recent developments in messenger RNA and microRNA technology at each stage of a patient's progression through the natural history of cardiovascular disease, including evaluation of risk factors, prediction and detection of coronary artery disease and acute coronary syndromes, and finally, response to treatments for coronary artery disease and its sequelae including congestive heart failure.

Full Text

Duke Authors

Cited Authors

  • Friede, KA; Ginsburg, GS; Voora, D

Published Date

  • August 2015

Published In

Volume / Issue

  • 8 / 6

Start / End Page

  • 339 - 352

PubMed ID

  • 26089288

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

Digital Object Identifier (DOI)

  • 10.1007/s12265-015-9640-6


  • eng

Conference Location

  • United States