New approaches to HIV vaccine development.

Journal Article (Journal Article;Review)

Development of a safe and effective vaccine for HIV is a major global priority. However, to date, efforts to design an HIV vaccine with methods used for development of other successful viral vaccines have not succeeded due to HIV diversity, HIV integration into the host genome, and ability of HIV to consistently evade anti-viral immune responses. Recent success in isolation of potent broadly neutralizing antibodies (bnAbs), in discovery of mechanisms of bnAb induction, and in discovery of atypical mechanisms of CD8T cell killing of HIV-infected cells, have opened new avenues for strategies for HIV vaccine design.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF

Published Date

  • August 2015

Published In

Volume / Issue

  • 35 /

Start / End Page

  • 39 - 47

PubMed ID

  • 26056742

Pubmed Central ID

  • PMC4553082

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2015.05.007


  • eng

Conference Location

  • England