Deep tissue imaging using spectroscopic analysis of multiply scattered light
Scattering limits the penetration depth of most optical imaging techniques. Efforts to overcome this limitation often require complex optical or computational schemes. We have developed a new method of assessing tissue properties based on spectroscopic analysis of multiply scattered light. The technique, multispectral multiple-scattering low-coherence interferometry (ms2/LCI), uses coherence and spatial gating to produce images of tissue optical properties up to 9 mm deep, with millimeter-scale resolution. The capabilities of ms2/LCI are demonstrated using tissue phantoms composed of chicken breast. Discrimination of diseased and healthy tissues is shown through imaging and analysis of burns in ex vivo human skin samples. Our technique may provide a powerful way to assess burn depth and progression in sensitive, burned tissues where physical contact is undesirable.
Duke Scholars
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- 5102 Atomic, molecular and optical physics
- 1005 Communications Technologies
- 0906 Electrical and Electronic Engineering
- 0205 Optical Physics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- 5102 Atomic, molecular and optical physics
- 1005 Communications Technologies
- 0906 Electrical and Electronic Engineering
- 0205 Optical Physics