LOCAL TRANSLATION. Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling".

Journal Article (Journal Article)

Jan et al. (Research Articles, 7 November 2014, p. 716) propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytosol to the endoplasmic reticulum (ER) upon emergence of the signal peptide and return to the cytosol after termination. An accounting of controls demonstrates that mRNAs initiate translation on ER-bound ribosomes and that ribosomes are retained on the ER through many cycles of translation.

Full Text

Duke Authors

Cited Authors

  • Reid, DW; Nicchitta, CV

Published Date

  • June 12, 2015

Published In

Volume / Issue

  • 348 / 6240

Start / End Page

  • 1217 -

PubMed ID

  • 26068841

Pubmed Central ID

  • PMC4862200

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aaa7257


  • eng

Conference Location

  • United States