The differential expression of IL-4 and IL-13 and its impact on type-2 immunity.


Journal Article (Review)

Allergic disease represents a significant global health burden, and disease incidence continues to rise in urban areas of the world. As such, a better understanding of the basic immune mechanisms underlying disease pathology are key to developing therapeutic interventions to both prevent disease onset as well as to ameliorate disease morbidity in those individuals already suffering from a disorder linked to type-2 inflammation. Two factors central to type-2 immunity are interleukin (IL)-4 and IL-13, which have been linked to virtually all major hallmarks associated with type-2 inflammation. Therefore, IL-4 and IL-13 and their regulatory pathways represent ideal targets to suppress disease. Despite sharing many common regulatory pathways and receptors, these cytokines perform very distinct functions during a type-2 immune response. This review summarizes the literature surrounding the function and expression of IL-4 and IL-13 in CD4+ T cells and innate immune cells. It highlights recent findings in vivo regarding the differential expression and non-canonical regulation of IL-4 and IL-13 in various immune cells, which likely play important and underappreciated roles in type-2 immunity.

Full Text

Cited Authors

  • Bao, K; Reinhardt, RL

Published Date

  • September 2015

Published In

Volume / Issue

  • 75 / 1

Start / End Page

  • 25 - 37

PubMed ID

  • 26073683

Pubmed Central ID

  • 26073683

Electronic International Standard Serial Number (EISSN)

  • 1096-0023

Digital Object Identifier (DOI)

  • 10.1016/j.cyto.2015.05.008


  • eng

Conference Location

  • England