Copper at the Fungal Pathogen-Host Axis.

Published

Journal Article (Review)

Fungal infections are responsible for millions of human deaths annually. Copper, an essential but toxic trace element, plays an important role at the host-pathogen axis during infection. In this review, we describe how the host uses either Cu compartmentalization within innate immune cells or Cu sequestration in other infected host niches such as in the brain to combat fungal infections. We explore Cu toxicity mechanisms and the Cu homeostasis machinery that fungal pathogens bring into play to succeed in establishing an infection. Finally, we address recent approaches that manipulate Cu-dependent processes at the host-pathogen axis for antifungal drug development.

Full Text

Duke Authors

Cited Authors

  • García-Santamarina, S; Thiele, DJ

Published Date

  • July 2015

Published In

Volume / Issue

  • 290 / 31

Start / End Page

  • 18945 - 18953

PubMed ID

  • 26055724

Pubmed Central ID

  • 26055724

Electronic International Standard Serial Number (EISSN)

  • 1083-351X

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.R115.649129

Language

  • eng