Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006
Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.
Duke Scholars
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- Microbiology
- 4203 Health services and systems
- 4202 Epidemiology
- 3202 Clinical sciences
- 1117 Public Health and Health Services
- 1108 Medical Microbiology
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Microbiology
- 4203 Health services and systems
- 4202 Epidemiology
- 3202 Clinical sciences
- 1117 Public Health and Health Services
- 1108 Medical Microbiology
- 1103 Clinical Sciences