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SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy.

Publication ,  Journal Article
Poplawski, L; Li, T; Chino, J; Craciunescu, O
Published in: Med Phys
June 2015

PURPOSE: In brachytherapy, structures surrounding the target have the potential to move between treatments and receive unknown dose. Deformable image registration could overcome challenges through dose accumulation. This study uses two possible deformable dose summation techniques and compares the results to point dose summation currently performed in clinic. METHODS: Data for ten patients treated with a Syed template was imported into the MIM software (Cleveland, OH). The deformable registration was applied to structures by masking other image data to a single intensity. The registration flow consisted of the following steps: 1) mask CTs so that each of the structures-of-interest had one unique intensity; 2) perform applicator - based rigid registration; 3) Perform deformable registration; 4) Refine registration by changing local alignments manually; 5) Repeat steps 1 to 3 until desired structure adequately deformed; 5) Transfer each deformed contours to the first CT. The deformed structure accuracy was determined by a dice similarity coefficient (DSC) comparison with the first fraction. Two dose summation techniques were investigated: a deformation and recalculation on the structure; and a dose deformation and accumulation method. Point doses were used as a comparison value. RESULTS: The Syed deformations have DSC ranging from 0.53 to 0.97 and 0.75 and 0.95 for the bladder and rectum, respectively. For the bladder, contour deformation addition ranged from -34.8% to 0.98% and dose deformation accumulation ranged from -35% to 29.3% difference from clinical calculations. For the rectum, contour deformation addition ranged from -5.2% to 16.9% and the dose deformation accumulation ranged from -29.1% to 15.3% change. CONCLUSION: Deforming dose for summation leads to different volumetric doses than when dose is recalculated on deformed structures, raising concerns about the accuracy of the deformed dose. DSC alone cannot be used to establish the accuracy of a deformation for brachy dose summation purpose.

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Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3288

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
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ICMJE
MLA
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Poplawski, L., Li, T., Chino, J., & Craciunescu, O. (2015). SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy. Med Phys, 42(6), 3288. https://doi.org/10.1118/1.4924192
Poplawski, L., T. Li, J. Chino, and O. Craciunescu. “SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy.Med Phys 42, no. 6 (June 2015): 3288. https://doi.org/10.1118/1.4924192.
Poplawski L, Li T, Chino J, Craciunescu O. SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy. Med Phys. 2015 Jun;42(6):3288.
Poplawski, L., et al. “SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy.Med Phys, vol. 42, no. 6, June 2015, p. 3288. Pubmed, doi:10.1118/1.4924192.
Poplawski L, Li T, Chino J, Craciunescu O. SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy. Med Phys. 2015 Jun;42(6):3288.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2015

Volume

42

Issue

6

Start / End Page

3288

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences