Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.

Journal Article

We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.

Full Text

Duke Authors

Cited Authors

  • Naggie, S; Patel, K; Yang, L-Y; Chow, S-C; Johnson, V; Guyton, JR; Muir, AJ; Sulkowski, M; Hicks, C

Published Date

  • April 2015

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • ofv066 -

PubMed ID

  • 26110167

Electronic International Standard Serial Number (EISSN)

  • 2328-8957

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofv066

Language

  • eng