Diamond for biosensing: Electrochemical detection of NOx species with thiol-amine functionalized diamond

Journal Article (Journal Article)

Diamond has long been of interest as a biomaterial due to its expected biocompatibility and chemical stability. Progress in surface functionalization of diamond and diamond electrochemistry has extended this interest to use as a biosensor platform. The sensitivity and selectivity of the diamond surface can be enhanced by covalently attaching carbon-based biochemicals. In this communication, an amine-thiol molecule was attached to a boron-doped diamond (BDD) surface to produce an enhanced ability to detect NO species. In the case of hydrogen terminated BDD, it was found that NO (aqueous) oxidation was insufficiently distinct to electrochemically detect NO. However, the amine-thiol functionalized BDD surface provided a distinct oxidation peak from 65 nanomolar to 236 nanomolar concentrations. Multiple cyclic voltammagrams with amine-thiol functionalized BDD electrode in (HPLC-quality) purified water indicated that the covalently attached surface molecules resisted decomposition during both anodic and cathodic polarization.

Full Text

Duke Authors

Cited Authors

  • Sund, JB; Wolter, SD; Parker, CB; Natishan, PM; Glass, JT

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 162 / 8

Start / End Page

  • B225 - B229

Electronic International Standard Serial Number (EISSN)

  • 1945-7111

International Standard Serial Number (ISSN)

  • 0013-4651

Digital Object Identifier (DOI)

  • 10.1149/2.0691508jes

Citation Source

  • Scopus