Non-invasive primate head restraint using thermoplastic masks.

Published

Journal Article

BACKGROUND: The success of many neuroscientific studies depends upon adequate head fixation of awake, behaving animals. Typically, this is achieved by surgically affixing a head-restraint prosthesis to the skull. NEW METHOD: Here we report the use of thermoplastic masks to non-invasively restrain monkeys' heads. Mesh thermoplastic sheets become pliable when heated and can then be molded to an individual monkey's head. After cooling, the custom mask retains this shape indefinitely for day-to-day use. RESULTS: We successfully trained rhesus macaques (Macaca mulatta) to perform cognitive tasks while wearing thermoplastic masks. Using these masks, we achieved a level of head stability sufficient for high-resolution eye-tracking and intracranial electrophysiology. COMPARISON WITH EXISTING METHOD: Compared with traditional head-posts, we find that thermoplastic masks perform at least as well during infrared eye-tracking and single-neuron recordings, allow for clearer magnetic resonance image acquisition, enable freer placement of a transcranial magnetic stimulation coil, and impose lower financial and time costs on the lab. CONCLUSIONS: We conclude that thermoplastic masks are a viable non-invasive form of primate head restraint that enable a wide range of neuroscientific experiments.

Full Text

Cited Authors

  • Drucker, CB; Carlson, ML; Toda, K; DeWind, NK; Platt, ML

Published Date

  • September 30, 2015

Published In

Volume / Issue

  • 253 /

Start / End Page

  • 90 - 100

PubMed ID

  • 26112334

Pubmed Central ID

  • 26112334

Electronic International Standard Serial Number (EISSN)

  • 1872-678X

Digital Object Identifier (DOI)

  • 10.1016/j.jneumeth.2015.06.013

Language

  • eng

Conference Location

  • Netherlands