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Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Nagle, CM; Dixon, SC; Jensen, A; Kjaer, SK; Modugno, F; deFazio, A; Fereday, S; Hung, J; Johnatty, SE; Australian Ovarian Cancer Study Group, ...
Published in: Br J Cancer
September 1, 2015

BACKGROUND: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer. METHODS: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype. RESULTS: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ⩾35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant. CONCLUSIONS: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

September 1, 2015

Volume

113

Issue

5

Start / End Page

817 / 826

Location

England

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasms, Glandular and Epithelial
  • Kaplan-Meier Estimate
  • Humans
  • Female
  • Disease-Free Survival
  • Carcinoma, Ovarian Epithelial
  • Body Mass Index
 

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Nagle, C. M., Dixon, S. C., Jensen, A., Kjaer, S. K., Modugno, F., deFazio, A., … Ovarian Cancer Association Consortium, . (2015). Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. Br J Cancer, 113(5), 817–826. https://doi.org/10.1038/bjc.2015.245
Nagle, C. M., S. C. Dixon, A. Jensen, S. K. Kjaer, F. Modugno, A. deFazio, S. Fereday, et al. “Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.Br J Cancer 113, no. 5 (September 1, 2015): 817–26. https://doi.org/10.1038/bjc.2015.245.
Nagle CM, Dixon SC, Jensen A, Kjaer SK, Modugno F, deFazio A, et al. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. Br J Cancer. 2015 Sep 1;113(5):817–26.
Nagle, C. M., et al. “Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.Br J Cancer, vol. 113, no. 5, Sept. 2015, pp. 817–26. Pubmed, doi:10.1038/bjc.2015.245.
Nagle CM, Dixon SC, Jensen A, Kjaer SK, Modugno F, deFazio A, Fereday S, Hung J, Johnatty SE, Australian Ovarian Cancer Study Group, Fasching PA, Beckmann MW, Lambrechts D, Vergote I, Van Nieuwenhuysen E, Lambrechts S, Risch HA, Rossing MA, Doherty JA, Wicklund KG, Chang-Claude J, Goodman MT, Ness RB, Moysich K, Heitz F, du Bois A, Harter P, Schwaab I, Matsuo K, Hosono S, Goode EL, Vierkant RA, Larson MC, Fridley BL, Høgdall C, Schildkraut JM, Weber RP, Cramer DW, Terry KL, Bandera EV, Paddock L, Rodriguez-Rodriguez L, Wentzensen N, Yang HP, Brinton LA, Lissowska J, Høgdall E, Lundvall L, Whittemore A, McGuire V, Sieh W, Rothstein J, Sutphen R, Anton-Culver H, Ziogas A, Pearce CL, Wu AH, Webb PM, Ovarian Cancer Association Consortium. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. Br J Cancer. 2015 Sep 1;113(5):817–826.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

September 1, 2015

Volume

113

Issue

5

Start / End Page

817 / 826

Location

England

Related Subject Headings

  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasms, Glandular and Epithelial
  • Kaplan-Meier Estimate
  • Humans
  • Female
  • Disease-Free Survival
  • Carcinoma, Ovarian Epithelial
  • Body Mass Index