The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease.

Journal Article (Journal Article)

Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study.

Full Text

Duke Authors

Cited Authors

  • Scialla, JJ

Published Date

  • July 2015

Published In

Volume / Issue

  • 88 / 1

Start / End Page

  • 9 - 11

PubMed ID

  • 26126088

Pubmed Central ID

  • PMC4487414

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1038/ki.2015.87


  • eng

Conference Location

  • United States