Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.

Journal Article (Journal Article)

The present study examined the association between genetic variation in the nicotinic receptor gene family (CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNA10, CHRNB2, CHRNB3, CHRNB4) and the occurrence of posttraumatic stress disorder (PTSD). Clinical interviews were used to diagnose PTSD in 925 non-Hispanic Black (NHB) and 743 non-Hispanic White (NHW) participants. Trauma history and smoking status were assessed with self-report. No significant main effects or single nucleotide polymorphism (SNP) * smoking interactions were observed among NHB participants; however, among NHW participants, a novel association between rs12898919 in the cholinergic receptor nicotinic alpha-5 (CHRNA5) gene and PTSD was observed. No other significant main effects or SNP * smoking interactions were identified among NHW participants. While preliminary, these findings provide continued support for the hypothesis that the CHRNA5 gene is associated with increased risk for PTSD. Limitations of the present study include cross-sectional design, relatively small sample sizes for genetic research, use of self-report to assess smoking status, and use of different methods to diagnose PTSD. Additional research in other samples of trauma-exposed participants is needed to identify the specific functional variant(s) responsible for the association observed between CHRNA5 and PTSD risk in the present study.

Full Text

Duke Authors

Cited Authors

  • Kimbrel, NA; Garrett, ME; Dennis, MF; Liu, Y; Patanam, I; Workgroup, VM-AM; Ashley-Koch, AE; Hauser, MA; Beckham, JC

Published Date

  • September 30, 2015

Published In

Volume / Issue

  • 229 / 1-2

Start / End Page

  • 326 - 331

PubMed ID

  • 26184988

Pubmed Central ID

  • PMC4697753

Electronic International Standard Serial Number (EISSN)

  • 1872-7123

Digital Object Identifier (DOI)

  • 10.1016/j.psychres.2015.07.002


  • eng

Conference Location

  • Ireland