Semi-degradable poly(β-amino ester) networks with temporally controlled enhancement of mechanical properties.

Journal Article

Biodegradable polymers are clinically used in numerous biomedical applications, and classically show a loss of mechanical properties within weeks of implantation. This work demonstrates a new class of semi-degradable polymers that show an increase in mechanical properties through degradation via a controlled shift in a thermal transition. Semi-degradable polymer networks, poly(β-amino ester)-co-methyl methacrylate, were formed from a low glass transition temperature crosslinker, poly(β-amino ester), and high glass transition temperature monomer, methyl methacrylate, which degraded in a manner dependent upon the crosslinker chemical structure. In vitro and in vivo degradation revealed changes in mechanical behavior due to the degradation of the crosslinker from the polymer network. This novel polymer system demonstrates a strategy to temporally control the mechanical behavior of polymers and to enhance the initial performance of smart biomedical devices.

Full Text

Duke Authors

Cited Authors

  • Safranski, DL; Weiss, D; Clark, JB; Taylor, WR; Gall, K

Published Date

  • August 2014

Published In

Volume / Issue

  • 10 / 8

Start / End Page

  • 3475 - 3483

PubMed ID

  • 24769113

Electronic International Standard Serial Number (EISSN)

  • 1878-7568

International Standard Serial Number (ISSN)

  • 1742-7061

Digital Object Identifier (DOI)

  • 10.1016/j.actbio.2014.04.022

Language

  • eng