Thermo-Mechanical Properties of Semi-Degradable Poly(β-amino ester)-co-Methyl Methacrylate Networks under Simulated Physiological Conditions.

Published

Journal Article

Poly(β-amino ester) networks are being explored for biomedical applications, but they may lack the mechanical properties necessary for long term implantation. The objective of this study is to evaluate the effect of adding methyl methacrylate on networks' mechanical properties under simulated physiological conditions. The networks were synthesized in two parts: (1) a biodegradable crosslinker was formed from a diacrylate and amine, (2) and then varying concentrations of methyl methacrylate were added prior to photopolymerizing the network. Degradation rate, mechanical properties, and glass transition temperature were studied as a function of methyl methacrylate composition. The crosslinking density played a limited role on mechanical properties for these networks, but increasing methyl methacrylate concentration improved the toughness by several orders of magnitude. Under simulated physiological conditions, networks showed increasing toughness or sustained toughness as degradation occurred. This work establishes a method of creating degradable networks with tailorable toughness while undergoing partial degradation.

Full Text

Duke Authors

Cited Authors

  • Safranski, DL; Crabtree, JC; Huq, YR; Gall, K

Published Date

  • September 2011

Published In

Volume / Issue

  • 52 / 21

Start / End Page

  • 4920 - 4927

PubMed ID

  • 21966028

Pubmed Central ID

  • 21966028

Electronic International Standard Serial Number (EISSN)

  • 1873-2291

International Standard Serial Number (ISSN)

  • 0032-3861

Digital Object Identifier (DOI)

  • 10.1016/j.polymer.2011.08.033

Language

  • eng