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A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Publication ,  Journal Article
Liu, Y; Ashton, JR; Moding, EJ; Yuan, H; Register, JK; Fales, AM; Choi, J; Whitley, MJ; Zhao, X; Qi, Y; Ma, Y; Vaidyanathan, G; Zalutsky, MR ...
Published in: Theranostics
2015

Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed a gold nanostar (GNS) probe for multi-modality theranostics including surface-enhanced Raman scattering (SERS) detection, x-ray computed tomography (CT), two-photon luminescence (TPL) imaging, and photothermal therapy (PTT). We performed radiolabeling, as well as CT and optical imaging, to investigate the GNS probe's biodistribution and intratumoral uptake at both macroscopic and microscopic scales. We also characterized the performance of the GNS nanoprobe for in vitro photothermal heating and in vivo photothermal ablation of primary sarcomas in mice. The results showed that 30-nm GNS have higher tumor uptake, as well as deeper penetration into tumor interstitial space compared to 60-nm GNS. In addition, we found that a higher injection dose of GNS can increase the percentage of tumor uptake. We also demonstrated the GNS probe's superior photothermal conversion efficiency with a highly concentrated heating effect due to a tip-enhanced plasmonic effect. In vivo photothermal therapy with a near-infrared (NIR) laser under the maximum permissible exposure (MPE) led to ablation of aggressive tumors containing GNS, but had no effect in the absence of GNS. This multifunctional GNS probe has the potential to be used for in vivo biosensing, preoperative CT imaging, intraoperative detection with optical methods (SERS and TPL), as well as image-guided photothermal therapy.

Duke Scholars

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Published In

Theranostics

DOI

EISSN

1838-7640

Publication Date

2015

Volume

5

Issue

9

Start / End Page

946 / 960

Location

Australia

Related Subject Headings

  • Treatment Outcome
  • Theranostic Nanomedicine
  • Sarcoma
  • Optical Imaging
  • Models, Animal
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Gold
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Y., Ashton, J. R., Moding, E. J., Yuan, H., Register, J. K., Fales, A. M., … Vo-Dinh, T. (2015). A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. Theranostics, 5(9), 946–960. https://doi.org/10.7150/thno.11974
Liu, Yang, Jeffrey R. Ashton, Everett J. Moding, Hsiangkuo Yuan, Janna K. Register, Andrew M. Fales, Jaeyeon Choi, et al. “A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.Theranostics 5, no. 9 (2015): 946–60. https://doi.org/10.7150/thno.11974.
Liu Y, Ashton JR, Moding EJ, Yuan H, Register JK, Fales AM, et al. A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. Theranostics. 2015;5(9):946–60.
Liu, Yang, et al. “A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.Theranostics, vol. 5, no. 9, 2015, pp. 946–60. Pubmed, doi:10.7150/thno.11974.
Liu Y, Ashton JR, Moding EJ, Yuan H, Register JK, Fales AM, Choi J, Whitley MJ, Zhao X, Qi Y, Ma Y, Vaidyanathan G, Zalutsky MR, Kirsch DG, Badea CT, Vo-Dinh T. A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. Theranostics. 2015;5(9):946–960.

Published In

Theranostics

DOI

EISSN

1838-7640

Publication Date

2015

Volume

5

Issue

9

Start / End Page

946 / 960

Location

Australia

Related Subject Headings

  • Treatment Outcome
  • Theranostic Nanomedicine
  • Sarcoma
  • Optical Imaging
  • Models, Animal
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Gold
  • Animals