Liver disease in menopause.

Published

Journal Article (Review)

There are numerous physiologic and biochemical changes in menopause that can affect the function of the liver and mediate the development of liver disease. Menopause represents a state of growing estrogen deficiency, and this loss of estrogen in the setting of physiologic aging increases the likelihood of mitochondrial dysfunction, cellular senescence, declining immune responses to injury, and disarray in the balance between antioxidant formation and oxidative stress. The sum effect of these changes can contribute to increased susceptibility to development of significant liver pathology, particularly nonalcoholic fatty liver disease and hepatocellular carcinoma, as well as accelerated progression of fibrosis in liver diseases, as has been particularly demonstrated in hepatitis C virus liver disease. Recognition of the unique nature of these mediating factors should raise suspicion for liver disease in perimenopausal and menopausal women and offer an opportunity for implementation of aggressive treatment measures so as to avoid progression of liver disease to cirrhosis, liver cancer and liver failure.

Full Text

Duke Authors

Cited Authors

  • Brady, CW

Published Date

  • July 2015

Published In

Volume / Issue

  • 21 / 25

Start / End Page

  • 7613 - 7620

PubMed ID

  • 26167064

Pubmed Central ID

  • 26167064

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

International Standard Serial Number (ISSN)

  • 1007-9327

Digital Object Identifier (DOI)

  • 10.3748/wjg.v21.i25.7613

Language

  • eng