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Personalized targeted therapy for esophageal squamous cell carcinoma.

Publication ,  Journal Article
Kang, X; Chen, K; Li, Y; Li, J; D'Amico, TA; Chen, X
Published in: World J Gastroenterol
July 7, 2015

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

Duke Scholars

Published In

World J Gastroenterol

DOI

EISSN

2219-2840

Publication Date

July 7, 2015

Volume

21

Issue

25

Start / End Page

7648 / 7658

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Risk Factors
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Molecular Targeted Therapy
  • Molecular Diagnostic Techniques
  • Humans
  • Genomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kang, X., Chen, K., Li, Y., Li, J., D’Amico, T. A., & Chen, X. (2015). Personalized targeted therapy for esophageal squamous cell carcinoma. World J Gastroenterol, 21(25), 7648–7658. https://doi.org/10.3748/wjg.v21.i25.7648
Kang, Xiaozheng, Keneng Chen, Yicheng Li, Jianying Li, Thomas A. D’Amico, and Xiaoxin Chen. “Personalized targeted therapy for esophageal squamous cell carcinoma.World J Gastroenterol 21, no. 25 (July 7, 2015): 7648–58. https://doi.org/10.3748/wjg.v21.i25.7648.
Kang X, Chen K, Li Y, Li J, D’Amico TA, Chen X. Personalized targeted therapy for esophageal squamous cell carcinoma. World J Gastroenterol. 2015 Jul 7;21(25):7648–58.
Kang, Xiaozheng, et al. “Personalized targeted therapy for esophageal squamous cell carcinoma.World J Gastroenterol, vol. 21, no. 25, July 2015, pp. 7648–58. Pubmed, doi:10.3748/wjg.v21.i25.7648.
Kang X, Chen K, Li Y, Li J, D’Amico TA, Chen X. Personalized targeted therapy for esophageal squamous cell carcinoma. World J Gastroenterol. 2015 Jul 7;21(25):7648–7658.

Published In

World J Gastroenterol

DOI

EISSN

2219-2840

Publication Date

July 7, 2015

Volume

21

Issue

25

Start / End Page

7648 / 7658

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Signal Transduction
  • Risk Factors
  • Predictive Value of Tests
  • Precision Medicine
  • Phenotype
  • Molecular Targeted Therapy
  • Molecular Diagnostic Techniques
  • Humans
  • Genomics