Personalized targeted therapy for esophageal squamous cell carcinoma.

Journal Article (Journal Article;Review)

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

Full Text

Duke Authors

Cited Authors

  • Kang, X; Chen, K; Li, Y; Li, J; D'Amico, TA; Chen, X

Published Date

  • July 7, 2015

Published In

Volume / Issue

  • 21 / 25

Start / End Page

  • 7648 - 7658

PubMed ID

  • 26167067

Pubmed Central ID

  • PMC4491954

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

Digital Object Identifier (DOI)

  • 10.3748/wjg.v21.i25.7648


  • eng

Conference Location

  • United States