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A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Publication ,  Journal Article
Ravussin, E; Redman, LM; Rochon, J; Das, SK; Fontana, L; Kraus, WE; Romashkan, S; Williamson, DA; Meydani, SN; Villareal, DT; Smith, SR ...
Published in: J Gerontol A Biol Sci Med Sci
September 2015

BACKGROUND: Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. METHODS: To determine CR's feasibility, safety, and effects on predictors of longevity, disease risk factors, and quality of life in nonobese humans aged 21-51 years, 218 persons were randomized to a 2-year intervention designed to achieve 25% CR or to AL diet. Outcomes were change from baseline resting metabolic rate adjusted for weight change ("RMR residual") and core temperature (primary); plasma triiodothyronine (T3) and tumor necrosis factor-α (secondary); and exploratory physiological and psychological measures. RESULTS: Body mass index averaged 25.1 (range: 21.9-28.0 kg/m(2)). Eighty-two percent of CR and 95% of AL participants completed the protocol. The CR group achieved 11.7±0.7 %CR (mean ± standard error) and maintained 10.4±0.4% weight loss. Weight change in AL was negligible. RMR residual decreased significantly more in CR than AL at 12 months (p = .04) but not 24 months (M24). Core temperature change differed little between groups. T3 decreased more in CR at M12 and M24 (p < .001), while tumor necrosis factor-α decreased significantly more only at M24 (p = .02). CR had larger decreases in cardiometabolic risk factors and in daily energy expenditure adjusted for weight change, without adverse effects on quality of life. CONCLUSIONS: Sustained CR is feasible in nonobese humans. The effects of the achieved CR on correlates of human survival and disease risk factors suggest potential benefits for aging-related outcomes that could be elucidated by further human studies.

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

September 2015

Volume

70

Issue

9

Start / End Page

1097 / 1104

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Tumor Necrosis Factor-alpha
  • Triiodothyronine
  • Time Factors
  • Middle Aged
  • Male
  • Longevity
  • Lipids
  • Humans
 

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Ravussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., … CALERIE Study Group, . (2015). A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci, 70(9), 1097–1104. https://doi.org/10.1093/gerona/glv057
Ravussin, Eric, Leanne M. Redman, James Rochon, Sai Krupa Das, Luigi Fontana, William E. Kraus, Sergei Romashkan, et al. “A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.J Gerontol A Biol Sci Med Sci 70, no. 9 (September 2015): 1097–1104. https://doi.org/10.1093/gerona/glv057.
Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, et al. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097–104.
Ravussin, Eric, et al. “A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.J Gerontol A Biol Sci Med Sci, vol. 70, no. 9, Sept. 2015, pp. 1097–104. Pubmed, doi:10.1093/gerona/glv057.
Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB, CALERIE Study Group. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1097–1104.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

September 2015

Volume

70

Issue

9

Start / End Page

1097 / 1104

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Tumor Necrosis Factor-alpha
  • Triiodothyronine
  • Time Factors
  • Middle Aged
  • Male
  • Longevity
  • Lipids
  • Humans