Abbreviated screening protocol for breast MRI: a feasibility study.
Journal Article (Journal Article)
RATIONALE AND OBJECTIVES: To compare the performance of two shortened breast magnetic resonance imaging (MRI) protocols to a standard MRI protocol for breast cancer screening. MATERIALS AND METHODS: In this Health Insurance Portability and Accountability Act compliant, institutional review board-approved pilot study, three fellowship-trained breast imagers evaluated 48 breast MRIs (24 normal, 12 benign, and 12 malignant) selected from a high-risk screening population. MRIs were presented in three viewing protocols, and a final Breast Imaging-Reporting and Data System assessment was recorded for each case. The first shortened protocol (abbreviated 1) included only fat-saturated precontrast T2-weighted, precontrast T1-weighted, and first pass T1-weighted postcontrast sequences. The second shortened protocol (abbreviated 2) included the abbreviated 1 protocol plus the second pass T1-weighted postcontrast sequence. The third protocol (full), reviewed after a 1-month waiting period, included a nonfat-saturated T1-weighted sequence, fat-saturated T2-weighted, precontrast T1-weighted, and three or four dynamic postcontrast sequences. Interpretation times were recorded for the abbreviated 1 and full protocols. Sensitivity and specificity were compared via a chi-squared analysis. This pilot study was designed to detect a 10% difference in sensitivity with a power of 0.8. RESULTS: There was no significant difference in sensitivity between the abbreviated 1 (86%; P = .22) or abbreviated 2 (89%; P = .38) protocols and the full protocol (95%). There was no significant difference in specificity between the abbreviated 1 (52%; P = 1) or abbreviated 2 (45%; P = .34) protocols and the full protocol (52%). The abbreviated 1 and full protocol interpretation times were similar (2.98 vs. 3.56 minutes). CONCLUSIONS: In this pilot study, reader performance comparing two shortened breast MRI protocols to a standard protocol in a screening cohort were similar, suggesting that a shortened breast MRI protocol may be clinically useful, warranting further investigation.
Full Text
Duke Authors
- Ghate, Sujata Vijay
- Grimm, Lars Johannes L
- Johnson, Karen Schwenk
- Kim, Connie Eunjung
- Soo, Mary Scott Campbell
- Yoon, Sora Christina
Cited Authors
- Grimm, LJ; Soo, MS; Yoon, S; Kim, C; Ghate, SV; Johnson, KS
Published Date
- September 2015
Published In
Volume / Issue
- 22 / 9
Start / End Page
- 1157 - 1162
PubMed ID
- 26152500
Electronic International Standard Serial Number (EISSN)
- 1878-4046
Digital Object Identifier (DOI)
- 10.1016/j.acra.2015.06.004
Language
- eng
Conference Location
- United States