Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.

Journal Article (Journal Article)

BACKGROUND: Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. METHODS: Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. RESULTS: A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). CONCLUSIONS: In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage.

Full Text

Duke Authors

Cited Authors

  • Feix, JA; Peery, CA; Gan, TJ; Warner, DS; James, ML; Zomorodi, A; McDonagh, DL

Published Date

  • 2015

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 350 -

PubMed ID

  • 26191477

Pubmed Central ID

  • PMC4502051

International Standard Serial Number (ISSN)

  • 2193-1801

Digital Object Identifier (DOI)

  • 10.1186/s40064-015-1126-0


  • eng

Conference Location

  • Switzerland