Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale.

Journal Article (Journal Article)

X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool by combining a numerical anthropomorphic phantom defined with non-uniform rational B-splines (NURBS) and a wave optics-based simulator that can accurately capture the phase-contrast signal from a human-scaled numerical phantom. Using a synchrotron-based, high-performance XPCI system, we provide qualitative comparison between simulated and experimental images. Our tool can be used to simulate the performance of XPCI on various disease entities and compare proposed XPCI systems in an unbiased manner.

Full Text

Duke Authors

Cited Authors

  • Sung, Y; Segars, WP; Pan, A; Ando, M; Sheppard, CJR; Gupta, R

Published Date

  • July 14, 2015

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 12011 -

PubMed ID

  • 26169570

Pubmed Central ID

  • PMC4500945

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep12011


  • eng

Conference Location

  • England