Consciousness recovery induced by intrathecal baclofen administration after subarachnoid hemorrhage -two case reports-.


Journal Article

Two patients with subarachnoid hemorrhage recovered consciousness after intrathecal baclofen administration using an implanted intrathecal baclofen pump delivering 50 microg per day using a simple infusion mode. Intrathecal baclofen resulted in significant reduction of spasticity 3 months after the implantation. Case 1 was reduced to a completely bedridden state with spasticity and could slightly move her fingers following commands. However, the patient could eat food and wash her face with minimal assistance at 3 months after the implantation, and could stand up in the parallel bars with assistance and speak several words at 8 months. Case 2 was in a completely bedridden state at 10 months after onset and could neither drink water nor follow instructions. However, the patient became oriented and could eat by herself within 3 to 4 weeks of implantation. She could walk with a cane and use the stairs with minimal assistance at 2 and 3 months after implantation. The patient could speak fluently within 6 months of implantation. Flatulence and dysuria happened during the screening test, but these symptoms were not repeated after implantation of a pump-catheter-system and continuous intrathecal baclofen infusion. Continuous intrathecal baclofen infusion caused both improvement in muscle tone and spasms and consciousness recovery from the vegetative state. This therapy is a strong candidate treatment for patients with spasticity and consciousness disturbance.

Full Text

Cited Authors

  • Oyama, H; Kito, A; Maki, H; Hattori, K; Tanahashi, K

Published Date

  • January 2010

Published In

Volume / Issue

  • 50 / 5

Start / End Page

  • 386 - 390

PubMed ID

  • 20505293

Pubmed Central ID

  • 20505293

Electronic International Standard Serial Number (EISSN)

  • 1349-8029

International Standard Serial Number (ISSN)

  • 0470-8105

Digital Object Identifier (DOI)

  • 10.2176/nmc.50.386


  • eng