Copper-catalyzed diamination of unactivated alkenes with hydroxylamines.

Journal Article (Journal Article)

A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with O -acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapid and efficient approach to construct a wide range of 1,2-diamines that are an important structural motif in organic synthesis, medicines, catalysts and ligands.

Full Text

Duke Authors

Cited Authors

  • Shen, K; Wang, Q

Published Date

  • July 2015

Published In

Volume / Issue

  • 6 / 7

Start / End Page

  • 4279 - 4283

PubMed ID

  • 29218196

Pubmed Central ID

  • PMC5707484

Electronic International Standard Serial Number (EISSN)

  • 2041-6539

International Standard Serial Number (ISSN)

  • 2041-6520

Digital Object Identifier (DOI)

  • 10.1039/c5sc00897b


  • eng