Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast


Journal Article

In diploid organisms, the frequency and nature of sexual cycles have a major impact on genome-wide patterns of heterozygosity. Recent population genomic surveys in the budding yeast, Saccharomyces cerevisiae, have revealed surprising levels of genomic heterozygosity in what has been traditionally considered a highly inbred organism. I review evidence and hypotheses regarding the generation, maintenance, and evolutionary consequences of genomic heterozygosity in S. cerevisiae. I propose that high levels of heterozygosity in S. cerevisiae, arising from population admixture due to human domestication, coupled with selfing during rare sexual cycles, can facilitate rapid adaptation to novel environments. © 2014 Springer Science+Business Media Dordrecht.

Full Text

Duke Authors

Cited Authors

  • Magwene, PM

Published Date

  • January 1, 2014

Published In

Volume / Issue

  • 781 /

Start / End Page

  • 37 - 48

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-94-7-7347-9_3

Citation Source

  • Scopus