Assessment of brain activity during memory encoding in a narcolepsy patient on and off modafinil using normative fMRI data.

Published

Journal Article

We present behavioral and functional magnetic resonance imaging (fMRI) findings of a 20-year-old female with narcolepsy who completed a standardized fMRI-adapted face memory task both 'off' and 'on' modafinil compared to a normative sample (N = 38). The patient showed poor recognition performance off modafinil (z = -2.03) but intact performance on modafinil (z = 0.78). fMRI results showed atypical activation during memory encoding off modafinil, with frontal lobe hypoactivity, but hippocampal hyperactivity, whereas all brain regions showed more normalized activation on modafinil. Results from this limited study suggest hippocampal and frontal alterations in individuals with narcolepsy. Further, the results suggest the hypothesis that modafinil may affect brain activation in some people with narcolepsy.

Full Text

Duke Authors

Cited Authors

  • Allen, MD; Hedges, DW; Farrer, TJ; Larson, MJ

Published Date

  • February 2012

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 13 - 25

PubMed ID

  • 21985031

Pubmed Central ID

  • 21985031

Electronic International Standard Serial Number (EISSN)

  • 1465-3656

Digital Object Identifier (DOI)

  • 10.1080/13554794.2010.547508

Language

  • eng

Conference Location

  • England