Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population.

Journal Article (Journal Article)

PURPOSE: To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. METHODS: Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis. RESULTS: There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32-529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = -91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = -2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup-disc ratio (VCDR). CONCLUSIONS: Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.

Full Text

Duke Authors

Cited Authors

  • Tun, TA; Sun, C-H; Baskaran, M; Girard, MJA; de Leon, JMS; Cheng, C-Y; Htoon, HM; Wong, TY; Aung, T; Strouthidis, NG

Published Date

  • May 2015

Published In

Volume / Issue

  • 56 / 5

Start / End Page

  • 3337 - 3344

PubMed ID

  • 26024117

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.15-16786


  • eng

Conference Location

  • United States