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Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population.

Publication ,  Journal Article
Tun, TA; Sun, C-H; Baskaran, M; Girard, MJA; de Leon, JMS; Cheng, C-Y; Htoon, HM; Wong, TY; Aung, T; Strouthidis, NG
Published in: Invest Ophthalmol Vis Sci
May 2015

PURPOSE: To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. METHODS: Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis. RESULTS: There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32-529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = -91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = -2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup-disc ratio (VCDR). CONCLUSIONS: Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.

Duke Scholars

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 2015

Volume

56

Issue

5

Start / End Page

3337 / 3344

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Optic Disk
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • China
  • Bruch Membrane
  • Basement Membrane
 

Citation

APA
Chicago
ICMJE
MLA
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Tun, T. A., Sun, C.-H., Baskaran, M., Girard, M. J. A., de Leon, J. M. S., Cheng, C.-Y., … Strouthidis, N. G. (2015). Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population. Invest Ophthalmol Vis Sci, 56(5), 3337–3344. https://doi.org/10.1167/iovs.15-16786
Tun, Tin A., Chen-Hsin Sun, Mani Baskaran, Michael J. A. Girard, John Mark S. de Leon, Ching-Yu Cheng, Hla M. Htoon, Tien Y. Wong, Tin Aung, and Nicholas G. Strouthidis. “Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population.Invest Ophthalmol Vis Sci 56, no. 5 (May 2015): 3337–44. https://doi.org/10.1167/iovs.15-16786.
Tun TA, Sun C-H, Baskaran M, Girard MJA, de Leon JMS, Cheng C-Y, et al. Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population. Invest Ophthalmol Vis Sci. 2015 May;56(5):3337–44.
Tun, Tin A., et al. “Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population.Invest Ophthalmol Vis Sci, vol. 56, no. 5, May 2015, pp. 3337–44. Pubmed, doi:10.1167/iovs.15-16786.
Tun TA, Sun C-H, Baskaran M, Girard MJA, de Leon JMS, Cheng C-Y, Htoon HM, Wong TY, Aung T, Strouthidis NG. Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population. Invest Ophthalmol Vis Sci. 2015 May;56(5):3337–3344.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

May 2015

Volume

56

Issue

5

Start / End Page

3337 / 3344

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Optic Disk
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • China
  • Bruch Membrane
  • Basement Membrane