Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes.


Journal Article

AIMS: To determine the relationship between macular ganglion cell-inner plexiform layer (GC-IPL) thickness and optic disc/retinal nerve fibre layer (RNFL) parameters in non-glaucomatous eyes measured by spectral-domain optical coherence tomography (SD-OCT). METHODS: 491 non-glaucomatous Chinese aged 40-80 years were recruited from a population-based study and underwent standardised ophthalmic examination. SD-OCT was used to measure GC-IPL thickness, optic disc parameters and RNFL thickness. Univariate and multiple linear regression analyses were performed to assess the association between GC-IPL and optic disc/RNFL parameters. RESULTS: In univariate analyses, all RNFL parameters and rim area were significantly correlated with all macular GC-IPL parameters (p<0.001, r=0.12-0.56). In multiple regression analyses, after adjusting for age, gender, disc area, signal strength and axial length, average RNFL thickness (per µm decrease) was most strongly correlated with average GC-IPL thickness (β=-0.30, standardised β=-0.499, p<0.001) compared with other optic disc/RNFL parameters. CONCLUSIONS: Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.

Full Text

Duke Authors

Cited Authors

  • Tham, Y-C; Cheung, CY; Koh, VT; Cheng, C-Y; Sidhartha, E; Strouthidis, NG; Wong, TY; Aung, T

Published Date

  • December 2013

Published In

Volume / Issue

  • 97 / 12

Start / End Page

  • 1592 - 1597

PubMed ID

  • 24123901

Pubmed Central ID

  • 24123901

Electronic International Standard Serial Number (EISSN)

  • 1468-2079

Digital Object Identifier (DOI)

  • 10.1136/bjophthalmol-2013-303660


  • eng

Conference Location

  • England