Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes.
Published
Journal Article
AIMS: To determine the relationship between macular ganglion cell-inner plexiform layer (GC-IPL) thickness and optic disc/retinal nerve fibre layer (RNFL) parameters in non-glaucomatous eyes measured by spectral-domain optical coherence tomography (SD-OCT). METHODS: 491 non-glaucomatous Chinese aged 40-80 years were recruited from a population-based study and underwent standardised ophthalmic examination. SD-OCT was used to measure GC-IPL thickness, optic disc parameters and RNFL thickness. Univariate and multiple linear regression analyses were performed to assess the association between GC-IPL and optic disc/RNFL parameters. RESULTS: In univariate analyses, all RNFL parameters and rim area were significantly correlated with all macular GC-IPL parameters (p<0.001, r=0.12-0.56). In multiple regression analyses, after adjusting for age, gender, disc area, signal strength and axial length, average RNFL thickness (per µm decrease) was most strongly correlated with average GC-IPL thickness (β=-0.30, standardised β=-0.499, p<0.001) compared with other optic disc/RNFL parameters. CONCLUSIONS: Our study demonstrated only fair correlations between macular GC-IPL and optic disc/RNFL parameters measured by SD-OCT. This information is important for further evaluation of macular GC-IPL thickness as an additional marker in detecting glaucomatous damage and progression.
Full Text
Duke Authors
Cited Authors
- Tham, Y-C; Cheung, CY; Koh, VT; Cheng, C-Y; Sidhartha, E; Strouthidis, NG; Wong, TY; Aung, T
Published Date
- December 2013
Published In
Volume / Issue
- 97 / 12
Start / End Page
- 1592 - 1597
PubMed ID
- 24123901
Pubmed Central ID
- 24123901
Electronic International Standard Serial Number (EISSN)
- 1468-2079
Digital Object Identifier (DOI)
- 10.1136/bjophthalmol-2013-303660
Language
- eng
Conference Location
- England