Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation.

Journal Article

Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model systems for disease onset characterization. Zebrafish represent a powerful platform to model IBD using forward and reverse genetics, live imaging of transgenic lines and physiological assays. In this review, we address current models of IBD in zebrafish and newly developed reagents available for future studies.

Full Text

Duke Authors

Cited Authors

  • Marjoram, L; Bagnat, M

Published Date

  • June 2015

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 147 - 153

PubMed ID

  • 26236567

Electronic International Standard Serial Number (EISSN)

  • 2167-485X

International Standard Serial Number (ISSN)

  • 2167-485X

Digital Object Identifier (DOI)

  • 10.1007/s40139-015-0079-x

Language

  • eng