Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation.
Journal Article (Journal Article)
Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, contribute to significant morbidity and mortality globally. Despite an increase in incidence, IBD onset is still poorly understood. Mouse models of IBD recapitulate several aspects of human disease, but limited accessibility for live imaging and the lack of forward genetics highlight the need for new model systems for disease onset characterization. Zebrafish represent a powerful platform to model IBD using forward and reverse genetics, live imaging of transgenic lines and physiological assays. In this review, we address current models of IBD in zebrafish and newly developed reagents available for future studies.
Full Text
Duke Authors
Cited Authors
- Marjoram, L; Bagnat, M
Published Date
- June 1, 2015
Published In
Volume / Issue
- 3 / 2
Start / End Page
- 147 - 153
PubMed ID
- 26236567
Pubmed Central ID
- PMC4520400
International Standard Serial Number (ISSN)
- 2167-485X
Digital Object Identifier (DOI)
- 10.1007/s40139-015-0079-x
Language
- eng
Conference Location
- United States