B cells in rheumatoid synovitis.

Published

Journal Article (Review)

In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals.

Full Text

Duke Authors

Cited Authors

  • Weyand, CM; Seyler, TM; Goronzy, JJ

Published Date

  • 2005

Published In

Volume / Issue

  • 7 Suppl 3 /

Start / End Page

  • S9 - 12

PubMed ID

  • 15960820

Pubmed Central ID

  • 15960820

Electronic International Standard Serial Number (EISSN)

  • 1478-6362

Digital Object Identifier (DOI)

  • 10.1186/ar1737

Language

  • eng

Conference Location

  • England