Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.

Published online

Journal Article

BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

Full Text

Duke Authors

Cited Authors

  • Diaz, LA; Foss, CA; Thornton, K; Nimmagadda, S; Endres, CJ; Uzuner, O; Seyler, TM; Ulrich, SD; Conway, J; Bettegowda, C; Agrawal, N; Cheong, I; Zhang, X; Ladenson, PW; Vogelstein, BN; Mont, MA; Zhou, S; Kinzler, KW; Vogelstein, B; Pomper, MG

Published Date

  • October 10, 2007

Published In

Volume / Issue

  • 2 / 10

Start / End Page

  • e1007 -

PubMed ID

  • 17925855

Pubmed Central ID

  • 17925855

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0001007

Language

  • eng

Conference Location

  • United States