Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.
Diaz, LA; Foss, CA; Thornton, K; Nimmagadda, S; Endres, CJ; Uzuner, O; Seyler, TM; Ulrich, SD; Conway, J; Bettegowda, C; Agrawal, N; Cheong, I; Zhang, X; Ladenson, PW; Vogelstein, BN; Mont, MA; Zhou, S; Kinzler, KW; Vogelstein, B; Pomper, MG
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