Recent scientific advances in leiomyoma (uterine fibroids) research facilitates better understanding and management.

Published online

Journal Article (Review)

Uterine leiomyomas (fibroids) are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred over the past five years, an effective pharmaceutical approach remains elusive. Further, there is currently no clinical method to distinguish a benign uterine leiomyoma from a malignant leiomyosarcoma prior to treatment, a pressing need given concerns about the use of the power morcellator for minimally invasive surgery. This paper reviews current studies regarding the molecular biology of uterine fibroids, discusses non-surgical approaches and suggests new cutting-edge therapeutic and diagnostic approaches.

Full Text

Duke Authors

Cited Authors

  • Taylor, DK; Holthouser, K; Segars, JH; Leppert, PC

Published Date

  • 2015

Published In

Volume / Issue

  • 4 / F1000 Faculty Rev

Start / End Page

  • 183 -

PubMed ID

  • 26236472

Pubmed Central ID

  • 26236472

International Standard Serial Number (ISSN)

  • 2046-1402

Digital Object Identifier (DOI)

  • 10.12688/f1000research.6189.1

Language

  • eng

Conference Location

  • England