Circuit Oxygenator Contributes to Extracorporeal Membrane Oxygenation-Induced Hemolysis


Journal Article

© 2014 by the American Society for Artificial Internal Organs. Hemolysis can occur as a consequence of extracorporeal membrane oxygenation (ECMO) and is associated with increased mortality and morbidity. Shear stress generated by flow through the circuit and oxygenator is believed to cause ECMO-induced hemolysis. We hypothesize that either a smaller dimension oxygenator or an in-line hemofilter will increase ECMO-associated hemolysis. Circuits were configured with a Quadrox-D Adult oxygenator (surface area 1.8 m2 ), Quadrox-iD Pediatric oxygenator (surface area 0.8 m2 ), or Quadrox-D Adult oxygenator with an in-line hemofilter (N = 4) and ran for 6 hours. Samples were collected hourly from the ECMO circuit and a time-based hemolysis control. Plasma hemoglobin levels were assayed. Circuit-induced hemolysis at each time point was defined as the change in plasma hemoglobin standardized to the time-based hemolysis control. Plasma hemoglobin increased with the use of the smaller dimension pediatric oxygenator as compared with the adult oxygenator when controlling for ECMO run time (p = 0.02). Furthermore, there was a greater pressure gradient with the smaller dimension pediatric oxygenator (p < 0.05). Plasma hemoglobin did not change with the addition of the in-line hemofilter. The use of a smaller dimension pediatric oxygenator resulted in greater hemolysis and a higher pressure gradient. This may indicate that the increased shear forces augment ECMO-induced hemolysis.

Full Text

Duke Authors

Cited Authors

  • Williams, DC; Turi, JL; Hornik, CP; Bonadonna, DK; Williford, WL; Walczak, RJ; Watt, KM; Cheifetz, IM

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 61 / 2

Start / End Page

  • 190 - 195

Electronic International Standard Serial Number (EISSN)

  • 1538-943X

International Standard Serial Number (ISSN)

  • 1058-2916

Digital Object Identifier (DOI)

  • 10.1097/MAT.0000000000000173

Citation Source

  • Scopus