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Brain volumes in psychotic youth with schizophrenia and mood disorders.

Publication ,  Journal Article
El-Sayed, M; Steen, RG; Poe, MD; Bethea, TC; Gerig, G; Lieberman, J; Sikich, L
Published in: J Psychiatry Neurosci
July 2010

BACKGROUND: We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD). METHODS: We used magnetic resonance imaging to examine brain volume in 24 psychotic youth (13 male, 11 female) with EOSS (n = 12) or EOMD (n = 12) and 17 healthy controls (10 male, 7 female). We measured the volume of grey and white matter using an automated segmentation program. RESULTS: After adjustment for age and intracranial volume, whole brain volume was lower in the EOSS patients than in the healthy controls (p = 0.001) and EOMD patients (p = 0.002). The EOSS patients had a deficit in grey matter volume (p = 0.005), especially in the frontal (p = 0.003) and parietal (p = 0.006) lobes, with no significant differences in white matter volume. LIMITATIONS: The main limitations of our study were its small sample size and the inclusion of patients with depression and mania in the affective group. CONCLUSION: Adolescents with EOSS have grey matter deficits compared with healthy controls and psychotic adolescents with EOMD. Our results suggest that grey matter deficits are not generally associated with psychosis but may be specifically associated with schizophrenia. Larger studies with consistent methods are needed to reconcile the contradictory findings among imaging studies involving psychotic youth.

Duke Scholars

Published In

J Psychiatry Neurosci

DOI

EISSN

1488-2434

Publication Date

July 2010

Volume

35

Issue

4

Start / End Page

229 / 236

Location

Canada

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Parietal Lobe
  • Mood Disorders
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
 

Citation

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El-Sayed, M., Steen, R. G., Poe, M. D., Bethea, T. C., Gerig, G., Lieberman, J., & Sikich, L. (2010). Brain volumes in psychotic youth with schizophrenia and mood disorders. J Psychiatry Neurosci, 35(4), 229–236. https://doi.org/10.1503/jpn.090051
El-Sayed, Mohamed, R Grant Steen, Michele D. Poe, T Carter Bethea, Guido Gerig, Jeffrey Lieberman, and Linmarie Sikich. “Brain volumes in psychotic youth with schizophrenia and mood disorders.J Psychiatry Neurosci 35, no. 4 (July 2010): 229–36. https://doi.org/10.1503/jpn.090051.
El-Sayed M, Steen RG, Poe MD, Bethea TC, Gerig G, Lieberman J, et al. Brain volumes in psychotic youth with schizophrenia and mood disorders. J Psychiatry Neurosci. 2010 Jul;35(4):229–36.
El-Sayed, Mohamed, et al. “Brain volumes in psychotic youth with schizophrenia and mood disorders.J Psychiatry Neurosci, vol. 35, no. 4, July 2010, pp. 229–36. Pubmed, doi:10.1503/jpn.090051.
El-Sayed M, Steen RG, Poe MD, Bethea TC, Gerig G, Lieberman J, Sikich L. Brain volumes in psychotic youth with schizophrenia and mood disorders. J Psychiatry Neurosci. 2010 Jul;35(4):229–236.

Published In

J Psychiatry Neurosci

DOI

EISSN

1488-2434

Publication Date

July 2010

Volume

35

Issue

4

Start / End Page

229 / 236

Location

Canada

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Parietal Lobe
  • Mood Disorders
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted