A Phase II study of a histamine H<inf>3</inf> receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy


Journal Article

© 2015 Elsevier B.V. This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H3 receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7weeks (4weeks titration). GSK239512 was associated with a small positive effect size (ES) on the CogState Schizophrenia Battery (CSSB) Composite Score (ES=0.29, CI=-0.40, 0.99) relative to placebo (primary endpoint). GSK239512's ES on CSSB domains were generally positive or neutral except Processing Speed, which favored placebo (ES=-0.46). Effects on the MATRICS Consensus Cognitive Battery were mostly neutral or favored placebo. GSK239512 was generally well tolerated with an adverse event profile consistent with the known class pharmacology. There was no evidence of overall beneficial effects of GSK239512 for CIAS in this population.

Full Text

Duke Authors

Cited Authors

  • Jarskog, LF; Lowy, MT; Grove, RA; Keefe, RSE; Horrigan, JP; Ball, MP; Breier, A; Buchanan, RW; Carter, CS; Csernansky, JG; Goff, DC; Green, MF; Kantrowitz, JT; Keshavan, MS; Laurelle, M; Lieberman, JA; Marder, SR; Maruff, P; McMahon, RP; Seidman, LJ; Peykamian, MA

Published Date

  • January 1, 2015

Published In

Volume / Issue

  • 164 / 1-3

Start / End Page

  • 136 - 142

Electronic International Standard Serial Number (EISSN)

  • 1573-2509

International Standard Serial Number (ISSN)

  • 0920-9964

Digital Object Identifier (DOI)

  • 10.1016/j.schres.2015.01.041

Citation Source

  • Scopus