mTOR and its tight regulation for iNKT cell development and effector function.

Journal Article (Journal Article;Review)

Invariant NKT (iNKT) cells, which express the invariant Vα14Jα18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalian target of rapamycin (mTOR) in immune cells, including iNKT. In this review we will discuss current understanding of how mTOR and its tight regulation control iNKT cell development, effector lineage differentiation, and function.

Full Text

Duke Authors

Cited Authors

  • Yang, W; Gorentla, B; Zhong, X-P; Shin, J

Published Date

  • December 2015

Published In

Volume / Issue

  • 68 / 2 Pt C

Start / End Page

  • 536 - 545

PubMed ID

  • 26253278

Pubmed Central ID

  • PMC4679438

Electronic International Standard Serial Number (EISSN)

  • 1872-9142

Digital Object Identifier (DOI)

  • 10.1016/j.molimm.2015.07.022


  • eng

Conference Location

  • England