Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern?

Journal Article (Journal Article)

PURPOSE: Aerobic exercise training in sedentary individuals improves physical fitness and various cardiovascular (CV) biomarkers. Nevertheless, there has been controversy as to whether exercise training may adversely affect some biomarkers in a small segment of the population. The purpose of this study was to investigate whether clinically significant worsening of CV biomarkers was more prevalent among individuals randomized to a supervised endurance training program as compared with those randomized to a control condition. METHODS: Baseline and end of study measurements of fasting insulin (FI), triglycerides (TG), resting systolic blood pressure (SBP), and HDL cholesterol (HDL-C) were obtained on 1188 healthy sedentary subjects from 4 clinical studies. Each study randomized subjects to 4- to 6-month supervised aerobic exercise programs or to a control group of no supervised exercise training. For each of the 4 CV biomarkers, we calculated the respective proportions of control and exercise group subjects whose baseline-to-follow-up changes were greater than or equal to previously reported adverse change (AC) thresholds. Those thresholds were increases of 24 pmol · L(-1) or greater for FI, 0.42 mmol · L(-1) or greater for TG, 10 mm Hg or greater for SBP, and a decrease of 0.12 mmol · L(-1) or greater for HDL-C. RESULTS: The respective proportions of subjects meeting the AC threshold in the control and exercise groups were 15.2% versus 9.6% (P = 0.02) for FI, 14.9% versus 13.1% (P = 0.37) for TG, 16.9% versus 15.8% (P = 0.52) for SBP, and 28.6% versus 22.5% (P = 0.03) for HDL-C. All were nonsignificant at the 0.0125 Bonferroni threshold adjusting for multiple comparisons. CONCLUSIONS: These findings do not support the concept that aerobic exercise training increases the risk of adverse changes in the CV biomarkers we studied.

Full Text

Duke Authors

Cited Authors

  • Leifer, ES; Mikus, CR; Karavirta, L; Resnick, BD; Kraus, WE; Häkkinen, K; Earnest, CP; Fleg, JL

Published Date

  • January 2016

Published In

Volume / Issue

  • 48 / 1

Start / End Page

  • 20 - 25

PubMed ID

  • 26258860

Pubmed Central ID

  • PMC4926311

Electronic International Standard Serial Number (EISSN)

  • 1530-0315

Digital Object Identifier (DOI)

  • 10.1249/MSS.0000000000000752


  • eng

Conference Location

  • United States