Prospects of immune checkpoint modulators in the treatment of glioblastoma.

Journal Article (Journal Article;Review)

Glioblastoma is the most common primary brain tumour in adults. Prognosis is poor: even with the current gold-standard first-line treatment—maximal safe resection and combination of radiotherapy with temozolomide chemotherapy—the median overall survival time is only approximately 15-17 months, because the tumour recurs in virtually all patients, and no commonly accepted standard treatment for recurrent disease exists. Several targeted agents have failed to improve patient outcomes in glioblastoma. Immunotherapy with immune checkpoint inhibitors such as ipilimumab, nivolumab, and pembrolizumab has provided relevant clinical improvements in other advanced tumours for which conventional therapies have had limited success, making immunotherapy an appealing strategy in glioblastoma. This Review summarizes current knowledge on immune checkpoint modulators and evaluates their potential role in glioblastoma on the basis of preclinical studies and emerging clinical data. Furthermore, we discuss challenges that need to be considered in the clinical development of drugs that target immune checkpoint pathways in glioblastoma, such as specific properties of the immune system in the CNS, issues with radiological response assessment, and potential interactions with established and emerging treatment strategies.

Full Text

Duke Authors

Cited Authors

  • Preusser, M; Lim, M; Hafler, DA; Reardon, DA; Sampson, JH

Published Date

  • September 2015

Published In

Volume / Issue

  • 11 / 9

Start / End Page

  • 504 - 514

PubMed ID

  • 26260659

Pubmed Central ID

  • PMC4782584

Electronic International Standard Serial Number (EISSN)

  • 1759-4766

Digital Object Identifier (DOI)

  • 10.1038/nrneurol.2015.139


  • eng

Conference Location

  • England