Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.
Publication
, Journal Article
Thiel, G; Marczinek, K; Neumann, R; Witkowski, R; Marchuk, DA; Nurnberg, P
Published in: Anticancer Res
1995
The increased frequency of glioma among neurofibromatosis 1 (NF1) patients suggests a general involvement of the NF1 gene in glioma tumourigenesis. Using the methodology of conventional Southern blotting with a complete panel of overlapping partial cDNAs covering the whole NF1 gene, we screened 31 gliomas of several different subtypes and 3 primitive neuroectodermal tumours (PNETs) from non-NF1 patients for aberrant restriction patterns in their tumour DNA samples. Clear evidence for somatic mutation events at the NF1 gene locus was found in 1 astrocytoma, 2 glioblastomas, 1 ependymoma and 1 PNET with an astrocytic component. These results suggest that the NF1 gene is important in suppressing tumours of neuroectodermal origin.
Duke Scholars
Published In
Anticancer Res
ISSN
0250-7005
Publication Date
1995
Volume
15
Issue
6B
Start / End Page
2495 / 2499
Location
Greece
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Oncology & Carcinogenesis
- Neuroectodermal Tumors
- Middle Aged
- Male
- Infant
- Humans
- Glioma
- Glioblastoma
- Genes, Neurofibromatosis 1
Citation
APA
Chicago
ICMJE
MLA
NLM
Thiel, G., Marczinek, K., Neumann, R., Witkowski, R., Marchuk, D. A., & Nurnberg, P. (1995). Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours. Anticancer Res, 15(6B), 2495–2499.
Thiel, G., K. Marczinek, R. Neumann, R. Witkowski, D. A. Marchuk, and P. Nurnberg. “Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.” Anticancer Res 15, no. 6B (1995): 2495–99.
Thiel G, Marczinek K, Neumann R, Witkowski R, Marchuk DA, Nurnberg P. Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours. Anticancer Res. 1995;15(6B):2495–9.
Thiel, G., et al. “Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.” Anticancer Res, vol. 15, no. 6B, 1995, pp. 2495–99.
Thiel G, Marczinek K, Neumann R, Witkowski R, Marchuk DA, Nurnberg P. Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours. Anticancer Res. 1995;15(6B):2495–2499.
Published In
Anticancer Res
ISSN
0250-7005
Publication Date
1995
Volume
15
Issue
6B
Start / End Page
2495 / 2499
Location
Greece
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Oncology & Carcinogenesis
- Neuroectodermal Tumors
- Middle Aged
- Male
- Infant
- Humans
- Glioma
- Glioblastoma
- Genes, Neurofibromatosis 1