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Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications.

Publication ,  Journal Article
Olsen, EA; Katz, HI; Levine, N; Nigra, TP; Pochi, PE; Savin, RC; Shupack, J; Weinstein, GD; Lufrano, L; Jou, HC
Published in: J Am Acad Dermatol
August 1997

BACKGROUND: Previous studies have documented reversal of long-term photodamage with once-daily applications of topical tretinoin. OBJECTIVE: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining improvement in photodamage with a reduced frequency of applications. METHODS: A total of 126 subjects who completed 48 weeks of once-daily treatment with tretinoin emollient cream 0.05% were enrolled for an additional 24 weeks of tretinoin once weekly, three times weekly, or no therapy. RESULTS: The clinical improvement observed during 48 weeks of once-daily treatment was sustained with three-times weekly applications and to a lesser extent with once-weekly dosing, whereas effects tended to regress in subjects off therapy. The overall incidence of adverse events in the skin and subcutaneous tissues appeared to vary with dose frequency. CONCLUSION: After 48 weeks of once-daily treatment, the continued use of tretinoin emollient cream 0.05% at a dose of three times per week maintains and, in some cases, may further enhance improvement in photodamage. Discontinuation of therapy results in some reversal of beneficial effects.

Duke Scholars

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1997

Volume

37

Issue

2 Pt 1

Start / End Page

227 / 230

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tretinoin
  • Skin Aging
  • Middle Aged
  • Male
  • Keratolytic Agents
  • Humans
  • Female
  • Drug Administration Schedule
  • Dose-Response Relationship, Drug
 

Citation

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Olsen, E. A., Katz, H. I., Levine, N., Nigra, T. P., Pochi, P. E., Savin, R. C., … Jou, H. C. (1997). Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. J Am Acad Dermatol, 37(2 Pt 1), 227–230. https://doi.org/10.1016/s0190-9622(97)80129-6
Olsen, E. A., H. I. Katz, N. Levine, T. P. Nigra, P. E. Pochi, R. C. Savin, J. Shupack, G. D. Weinstein, L. Lufrano, and H. C. Jou. “Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications.J Am Acad Dermatol 37, no. 2 Pt 1 (August 1997): 227–30. https://doi.org/10.1016/s0190-9622(97)80129-6.
Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, et al. Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):227–30.
Olsen, E. A., et al. “Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications.J Am Acad Dermatol, vol. 37, no. 2 Pt 1, Aug. 1997, pp. 227–30. Pubmed, doi:10.1016/s0190-9622(97)80129-6.
Olsen EA, Katz HI, Levine N, Nigra TP, Pochi PE, Savin RC, Shupack J, Weinstein GD, Lufrano L, Jou HC. Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):227–230.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

August 1997

Volume

37

Issue

2 Pt 1

Start / End Page

227 / 230

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Tretinoin
  • Skin Aging
  • Middle Aged
  • Male
  • Keratolytic Agents
  • Humans
  • Female
  • Drug Administration Schedule
  • Dose-Response Relationship, Drug