Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.

Published

Journal Article

Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism is a common feature of cancer cells, but little is known as to what metabolic changes benefit breast cancer brain metastases. We found that brain metastatic breast cancer cells evolved the ability to survive and proliferate independent of glucose due to enhanced gluconeogenesis and oxidations of glutamine and branched chain amino acids, which together sustain the nonoxidative pentose pathway for purine synthesis. Silencing expression of fructose-1,6-bisphosphatases (FBP) in brain metastatic cells reduced their viability and improved the survival of metastasis-bearing immunocompetent hosts. Clinically, we showed that brain metastases from human breast cancer patients expressed higher levels of FBP and glycogen than the corresponding primary tumors. Together, our findings identify a critical metabolic condition required to sustain brain metastasis and suggest that targeting gluconeogenesis may help eradicate this deadly feature in advanced breast cancer patients.

Full Text

Duke Authors

Cited Authors

  • Chen, J; Lee, H-J; Wu, X; Huo, L; Kim, S-J; Xu, L; Wang, Y; He, J; Bollu, LR; Gao, G; Su, F; Briggs, J; Liu, X; Melman, T; Asara, JM; Fidler, IJ; Cantley, LC; Locasale, JW; Weihua, Z

Published Date

  • February 2015

Published In

Volume / Issue

  • 75 / 3

Start / End Page

  • 554 - 565

PubMed ID

  • 25511375

Pubmed Central ID

  • 25511375

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-14-2268

Language

  • eng