Serine, glycine and one-carbon units: cancer metabolism in full circle.

Published

Journal Article (Review)

One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine.

Full Text

Duke Authors

Cited Authors

  • Locasale, JW

Published Date

  • August 2013

Published In

Volume / Issue

  • 13 / 8

Start / End Page

  • 572 - 583

PubMed ID

  • 23822983

Pubmed Central ID

  • 23822983

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/nrc3557

Language

  • eng

Conference Location

  • England