Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Published

Journal Article

Reprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how the expression of metabolic genes in tumors differs from that in normal tissues, or whether different tumor types exhibit similar metabolic changes. Here we compare expression patterns of metabolic genes across 22 diverse types of human tumors. Overall, the metabolic gene expression program in tumors is similar to that in the corresponding normal tissues. Although expression changes of some metabolic pathways (e.g., upregulation of nucleotide biosynthesis and glycolysis) are frequently observed across tumors, expression changes of other pathways (e.g., oxidative phosphorylation) are very heterogeneous. Our analysis also suggests that the expression changes of some metabolic genes (e.g., isocitrate dehydrogenase and fumarate hydratase) may enhance or mimic the effects of recurrent mutations in tumors. On the level of individual biochemical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expression changes. These isoenzymes are potential targets for anticancer therapy.

Full Text

Duke Authors

Cited Authors

  • Hu, J; Locasale, JW; Bielas, JH; O'Sullivan, J; Sheahan, K; Cantley, LC; Vander Heiden, MG; Vitkup, D

Published Date

  • June 2013

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 522 - 529

PubMed ID

  • 23604282

Pubmed Central ID

  • 23604282

Electronic International Standard Serial Number (EISSN)

  • 1546-1696

Digital Object Identifier (DOI)

  • 10.1038/nbt.2530

Language

  • eng

Conference Location

  • United States