Interactions between epigenetics and metabolism in cancers.

Journal Article (Journal Article)

Cancer progression is accompanied by widespread transcriptional changes and metabolic alterations. While it is widely accepted that the origin of cancer can be traced to the mutations that accumulate over time, relatively recent evidence favors a similarly fundamental role for alterations in the epigenome during tumorigenesis. Changes in epigenetics that arise from post-translational modifications of histones and DNA are exploited by cancer cells to upregulate and/or downregulate the expression levels of oncogenes and tumor suppressors, respectively. Although the mechanisms behind these modifications, in particular how they lead to gene silencing and activation, are still being understood, most of the enzymatic machinery of epigenetics require metabolites as substrates or cofactors. As a result, their activities can be influenced by the metabolic state of the cell. The purpose of this review is to give an overview of cancer epigenetics and metabolism and provide examples of where they converge.

Full Text

Duke Authors

Cited Authors

  • Yun, J; Johnson, JL; Hanigan, CL; Locasale, JW

Published Date

  • 2012

Published In

Volume / Issue

  • 2 /

Start / End Page

  • 163 -

PubMed ID

  • 23162793

Pubmed Central ID

  • PMC3498627

Electronic International Standard Serial Number (EISSN)

  • 2234-943X

Digital Object Identifier (DOI)

  • 10.3389/fonc.2012.00163


  • eng

Conference Location

  • Switzerland