PHGDH amplification and altered glucose metabolism in human melanoma.


Journal Article (Review)

The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.

Full Text

Duke Authors

Cited Authors

  • Mullarky, E; Mattaini, KR; Vander Heiden, MG; Cantley, LC; Locasale, JW

Published Date

  • December 2011

Published In

Volume / Issue

  • 24 / 6

Start / End Page

  • 1112 - 1115

PubMed ID

  • 21981974

Pubmed Central ID

  • 21981974

Electronic International Standard Serial Number (EISSN)

  • 1755-148X

Digital Object Identifier (DOI)

  • 10.1111/j.1755-148X.2011.00919.x


  • eng

Conference Location

  • England