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Metrology Standards for Quantitative Imaging Biomarkers.

Publication ,  Journal Article
Sullivan, DC; Obuchowski, NA; Kessler, LG; Raunig, DL; Gatsonis, C; Huang, EP; Kondratovich, M; McShane, LM; Reeves, AP; Barboriak, DP ...
Published in: Radiology
December 2015

Although investigators in the imaging community have been active in developing and evaluating quantitative imaging biomarkers (QIBs), the development and implementation of QIBs have been hampered by the inconsistent or incorrect use of terminology or methods for technical performance and statistical concepts. Technical performance is an assessment of how a test performs in reference objects or subjects under controlled conditions. In this article, some of the relevant statistical concepts are reviewed, methods that can be used for evaluating and comparing QIBs are described, and some of the technical performance issues related to imaging biomarkers are discussed. More consistent and correct use of terminology and study design principles will improve clinical research, advance regulatory science, and foster better care for patients who undergo imaging studies.

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Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

December 2015

Volume

277

Issue

3

Start / End Page

813 / 825

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Reproducibility of Results
  • Reference Values
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Diagnostic Imaging
  • Biomarkers
  • Bias
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sullivan, D. C., Obuchowski, N. A., Kessler, L. G., Raunig, D. L., Gatsonis, C., Huang, E. P., … RSNA-QIBA Metrology Working Group, . (2015). Metrology Standards for Quantitative Imaging Biomarkers. Radiology, 277(3), 813–825. https://doi.org/10.1148/radiol.2015142202
Sullivan, Daniel C., Nancy A. Obuchowski, Larry G. Kessler, David L. Raunig, Constantine Gatsonis, Erich P. Huang, Marina Kondratovich, et al. “Metrology Standards for Quantitative Imaging Biomarkers.Radiology 277, no. 3 (December 2015): 813–25. https://doi.org/10.1148/radiol.2015142202.
Sullivan DC, Obuchowski NA, Kessler LG, Raunig DL, Gatsonis C, Huang EP, et al. Metrology Standards for Quantitative Imaging Biomarkers. Radiology. 2015 Dec;277(3):813–25.
Sullivan, Daniel C., et al. “Metrology Standards for Quantitative Imaging Biomarkers.Radiology, vol. 277, no. 3, Dec. 2015, pp. 813–25. Pubmed, doi:10.1148/radiol.2015142202.
Sullivan DC, Obuchowski NA, Kessler LG, Raunig DL, Gatsonis C, Huang EP, Kondratovich M, McShane LM, Reeves AP, Barboriak DP, Guimaraes AR, Wahl RL, RSNA-QIBA Metrology Working Group. Metrology Standards for Quantitative Imaging Biomarkers. Radiology. 2015 Dec;277(3):813–825.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

December 2015

Volume

277

Issue

3

Start / End Page

813 / 825

Location

United States

Related Subject Headings

  • Terminology as Topic
  • Reproducibility of Results
  • Reference Values
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Diagnostic Imaging
  • Biomarkers
  • Bias
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences