Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.
Publication
, Journal Article
Murray, MK; Teran, VA; Chapleau, J-P; Wang, B; Kim, SH; LaBranche, CC; Richard, J; Montefiori, DC; Finzi, A; Yuan, W
Published in: J Virol
October 2015
CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC). Here we investigated the immunogenicity of soluble Env trimers (sgp140) from a CD4-independent HIV-1 in guinea pigs and found that the sgp140 elicited ADCC-mediating antibodies. Therefore, these sgp140 might be useful in vaccine regimens aimed at eliciting ADCC responses.
Duke Scholars
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
October 2015
Volume
89
Issue
20
Start / End Page
10707 / 10711
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Solubility
- Protein Multimerization
- Protein Binding
- Immunization
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies
Citation
APA
Chicago
ICMJE
MLA
NLM
Murray, M. K., Teran, V. A., Chapleau, J.-P., Wang, B., Kim, S. H., LaBranche, C. C., … Yuan, W. (2015). Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs. J Virol, 89(20), 10707–10711. https://doi.org/10.1128/JVI.01642-15
Murray, Marta K., Victor A. Teran, Jean-Philippe Chapleau, Baomin Wang, Su Hyon Kim, Celia C. LaBranche, Jonathan Richard, David C. Montefiori, Andrés Finzi, and Wen Yuan. “Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.” J Virol 89, no. 20 (October 2015): 10707–11. https://doi.org/10.1128/JVI.01642-15.
Murray MK, Teran VA, Chapleau J-P, Wang B, Kim SH, LaBranche CC, et al. Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs. J Virol. 2015 Oct;89(20):10707–11.
Murray, Marta K., et al. “Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.” J Virol, vol. 89, no. 20, Oct. 2015, pp. 10707–11. Pubmed, doi:10.1128/JVI.01642-15.
Murray MK, Teran VA, Chapleau J-P, Wang B, Kim SH, LaBranche CC, Richard J, Montefiori DC, Finzi A, Yuan W. Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs. J Virol. 2015 Oct;89(20):10707–10711.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
October 2015
Volume
89
Issue
20
Start / End Page
10707 / 10711
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Solubility
- Protein Multimerization
- Protein Binding
- Immunization
- Humans
- HIV-1
- HIV Infections
- HIV Antibodies