Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.

Journal Article (Journal Article)

CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC). Here we investigated the immunogenicity of soluble Env trimers (sgp140) from a CD4-independent HIV-1 in guinea pigs and found that the sgp140 elicited ADCC-mediating antibodies. Therefore, these sgp140 might be useful in vaccine regimens aimed at eliciting ADCC responses.

Full Text

Duke Authors

Cited Authors

  • Murray, MK; Teran, VA; Chapleau, J-P; Wang, B; Kim, SH; LaBranche, CC; Richard, J; Montefiori, DC; Finzi, A; Yuan, W

Published Date

  • October 2015

Published In

Volume / Issue

  • 89 / 20

Start / End Page

  • 10707 - 10711

PubMed ID

  • 26246571

Pubmed Central ID

  • PMC4580154

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.01642-15


  • eng

Conference Location

  • United States