Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

Journal Article (Journal Article)

In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging technology with real-time feedback of sclerotic skin disease diagnosis. This paper shows representative results from an ongoing study, recruiting patients with and without sclerosis. The stiffness of the imaged site was evaluated using two metrics: mean ARFI displacement magnitude and bulk shear wave speed inside the region of interest (ROI). In a subject with localized graft versus host disease (GVHD), the mean ARFI displacement inside sclerotic skin was 61% lower (p < 0.01) and shear wave speed 128% higher (p < 0.005) compared to those in normal skin-indicating stiffer mechanical properties in the sclerotic skin. This trend persisted through disease types. We conclude ARFI and SWEI can successfully differentiate sclerotic lesions from normal dermis.

Full Text

Duke Authors

Cited Authors

  • Lee, SY; Cardones, AR; Doherty, J; Nightingale, K; Palmeri, M

Published Date

  • November 2015

Published In

Volume / Issue

  • 41 / 11

Start / End Page

  • 2806 - 2819

PubMed ID

  • 26259888

Pubmed Central ID

  • PMC4593719

Electronic International Standard Serial Number (EISSN)

  • 1879-291X

Digital Object Identifier (DOI)

  • 10.1016/j.ultrasmedbio.2015.06.007


  • eng

Conference Location

  • England