Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates.

Journal Article (Journal Article)

We demonstrate the reversible micellar aggregation of a DNA-azobenzene conjugate in aqueous conditions, in which the photoisomerization of the initially apolar trans-azobenzene moiety to the polar cis isomer causes disassembly of the aggregates. The molecular basis for this phenomena is a change in the hydrophobic/hydrophilic balance of the conjugate as the more polar cis azobenzene isomer is formed upon exposure to 365 nm irradiation. The conjugates were prepared by copper-free Click chemistry between an azide-modified, 53-base ssDNA and a cyclooctyne derivative of azobenzene. The photocontrolled aggregation of the conjugate was studied by dynamic light scattering and atomic force microscopy. The reversible micellar aggregation for a DNA-azobenzene conjugate has not been previously reported and holds promise for photocontrolled drug delivery applications.

Full Text

Duke Authors

Cited Authors

  • Gu, R; Lamas, J; Rastogi, SK; Li, X; Brittain, W; Zauscher, S

Published Date

  • November 2015

Published In

Volume / Issue

  • 135 /

Start / End Page

  • 126 - 132

PubMed ID

  • 26247877

Electronic International Standard Serial Number (EISSN)

  • 1873-4367

International Standard Serial Number (ISSN)

  • 0927-7765

Digital Object Identifier (DOI)

  • 10.1016/j.colsurfb.2015.07.010


  • eng