Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates.
Journal Article (Journal Article)
We demonstrate the reversible micellar aggregation of a DNA-azobenzene conjugate in aqueous conditions, in which the photoisomerization of the initially apolar trans-azobenzene moiety to the polar cis isomer causes disassembly of the aggregates. The molecular basis for this phenomena is a change in the hydrophobic/hydrophilic balance of the conjugate as the more polar cis azobenzene isomer is formed upon exposure to 365 nm irradiation. The conjugates were prepared by copper-free Click chemistry between an azide-modified, 53-base ssDNA and a cyclooctyne derivative of azobenzene. The photocontrolled aggregation of the conjugate was studied by dynamic light scattering and atomic force microscopy. The reversible micellar aggregation for a DNA-azobenzene conjugate has not been previously reported and holds promise for photocontrolled drug delivery applications.
Full Text
Duke Authors
Cited Authors
- Gu, R; Lamas, J; Rastogi, SK; Li, X; Brittain, W; Zauscher, S
Published Date
- November 2015
Published In
Volume / Issue
- 135 /
Start / End Page
- 126 - 132
PubMed ID
- 26247877
Electronic International Standard Serial Number (EISSN)
- 1873-4367
International Standard Serial Number (ISSN)
- 0927-7765
Digital Object Identifier (DOI)
- 10.1016/j.colsurfb.2015.07.010
Language
- eng